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The Legend of the
Luteal Phase Defect
The menstrual cycle is a monthly reminder of both the
potential for fertility and the lack of pregnancy for women. This biologic
process is referred to by a variety of terms in our popular culture
including: “time of the month”, “I’m
on”, “my period”, “A.F. (Auntie Flow)” and even sarcastically “my friend”. For
those wishing to avoid pregnancy, especially those with lapses in birth control
usage, the onset of one’s period comes as a relief. However, women who want to
become pregnant may dread the start of menses and the reminder that they have
not achieved their goal. The pursuit of fertility is also hampered by the many
misconceptions that exist regarding the normal length of the menstrual cycle
and the optimal time to achieve pregnancy. The OV-Watch is based on the well
established science of the fertility window. Fertility is enhanced and the time
required to get pregnant is shortened, when a couple accurately identifies this
window of opportunity several days BEFORE ovulation. During the fertility window, intercourse has
the potential to result in pregnancy as the sperm remain viable for several
days awaiting the release of the egg.
Identifying ovulation at the last minute or after the fact is unlikely
to result in a pregnancy as the egg may no longer be receptive to the
sperm. Likewise, there are many other
myths about getting pregnant and issues surrounding normal hormone
fluctuations. Chief among these misconceptions is the “Legend of the Luteal
Phase Defect”.
The Luteal Phase is the second half of the cycle, from
ovulation until the onset of menses and is extremely consistent in length, 13 –
15 days. The first half of the cycle (from the onset of bleeding until
ovulation) varies considerably between women and accounts for the different
cycle lengths. The length of the
menstrual cycle, from the first day of menstrual flow to the start of the next
menses, has traditionally been recognized as 28 days. However, less than 1 in 6
women have cycles that are exactly 28 days in length. Approximately 2 out of 3 women have periods
that are 25 – 28 days, with most normal cycles ranging 24 to 35 days. It is important to note that cycle lengths
vary with age; slightly longer in the teens with a decrease in length and
variability until the mid 40s. The cycle begins to lengthen before stopping
when a woman reaches menopause. A
regular, predictable and consistent menstrual cycle is a very good indication
that a women is ovulating. Conversely,
an irregular, unpredictable or even absent cycle suggest that a woman is not
regularly releasing an egg and has decreased fertility. However, it is not uncommon for a woman to
have some variability (up to 7 days) in the length of her cycle from month to
month.
Much attention has been focused on the time after
ovulation, the luteal phase, and its correlation with implantation or
fertility. A Luteal Phase Deficiency or
low progesterone is often blamed for difficulty conceiving and early pregnancy
loss. The theory is that the site of the
egg release or corpus luteum produced inadequate progesterone resulting in a
uterine lining or endometrium that was not ready or capable of supporting the
embryo. The standard for diagnosing this
condition was a short (<13 days) or inadequate luteal phase. Traditionally,
an endometrial biopsy was also performed as part of the evaluation for
infertility, but the recent overwhelming evidence does not support the use of
this uncomfortable, invasive test. One
of the leading textbooks on fertility states that an endometrial biopsy:
“cannot be used to guide clinical management…and should no longer be regarded
as an important element of their evaluation”.
The samples of uterine tissue are not only difficult to interpret, but
many women who are very fertile will have abnormal results, raising the
question of the value of the test for infertility. A low progesterone level is often used to
diagnose a luteal phase defect and determine the need for progesterone
supplementation. However, a single blood
level for progesterone may not be helpful. Progesterone levels change rapidly
as they pulse up and down varying from as low as 2 ng/mL to as high as 40 ng/mL
after ovulation. Again, the textbook
states that serum progesterone levels “defy interpretation and have little
value beyond documenting ovulation”.
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